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Updated: Sep 13, 2025

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Association between serum corin in the second trimester and hypertensive disorders of pregnancy: a mendelian
Xueyang Zhang1, Qing Yu2, Junjiang Liu3
1Taixing Second People's Hospital, Suzhou Medical College of Soochow University, Taizhou, China; Department of Epidemiology, School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, China.
Background:
Serum corin has been associated with hypertensive disorders of pregnancy (HDP) in clinical studies but lacks causal evidence. This study aimed to systemically examine the associations of serum corin and its coding gene polymorphisms with HDP, as well as the underlying causality among Chinese pregnant women.
Methods:
A nested case-control study comprising 403 cases of HDP and 402 age- and parity-matched healthy controls was designed. Serum corin and its coding gene genotype (19 SNPs) were assayed before 20 gestational weeks. Their associations with HDP were systemically examined using gene-based and Mendelian Randomization (MR) approaches.
Results:
Serum corin was negatively associated with HDP (OR = 0.92, 95 %CI: 0.88-0.96, P = 0.025) even after adjusting for conventional risk factors. Most SNPs genotyped were associated with serum corin but none of them were associated with HDP, either individually or jointly (all P > 0.05). The MR analysis based on our own or summary data failed to observe a significant causal relationship between corin and HDP (P > 0.05).
Conclusion:
Deficient serum corin in early pregnancy indicates, but may not causally, an increased risk of HDP in Chinese women. The clinical translation of corin into HDP management needs further study.
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