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Ganoderma lucidum sporoderm-broken spore powder alleviates kidney aging by modulating gut microbiota

Xiaojing Liu1, Jiamin Zhao1, Jia Liu1

  • 1State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China.

Journal of Ethnopharmacology
|August 3, 2025
PubMed
Abstract

Insights

Ganoderma lucidum (G. lucidum) combats kidney aging by reshaping gut bacteria, boosting nicotinamide riboside (NR) to enhance NAD+ levels and regulate steroid metabolism, offering a novel anti-aging strategy.

Area of Science:

  • Aging Research
  • Microbiology
  • Pharmacology

Background:

  • Ganoderma lucidum (G. lucidum) is traditionally used for anti-aging and kidney protection.
  • Its mechanisms, particularly gut microbiota modulation in aging, require further elucidation.

Purpose of the Study:

  • To investigate the gut microbiota-dependent anti-aging effects of G. lucidum on renal and systemic senescence.
  • To explore the underlying mechanisms using multi-omics approaches.

Main Methods:

  • Evaluated G. lucidum sporoderm-broken spore powder (Gl-SBSP) in aged mouse models.
  • Assessed renal aging via histopathology, blood counts, ELISA, and RT-qPCR.
  • Confirmed gut microbiota roles using antibiotics and fecal microbiota transplantation (FMT).
  • Integrated 16S rRNA sequencing and metabolomics, with functional validation in cells and mice.

Main Results:

  • Gl-SBSP treatment attenuated kidney aging in both natural and induced senescence models.
  • It selectively enriched Lachnospiraceae bacteria.
  • The metabolite nicotinamide riboside (NR) was identified, which increased renal NAD+ levels, rejuvenated kidneys, and improved function via steroid metabolism regulation.

Conclusions:

  • Gl-SBSP exerts anti-renal aging effects through Lachnospiraceae-mediated gut microbiota remodeling.
  • Nicotinamide riboside (NR) is a key metabolite mediating rejuvenation by activating NAD+ biosynthesis and modulating steroid metabolism.
  • This highlights a novel therapeutic strategy for age-related kidney decline, supporting G. lucidum's ethnopharmacological use.
Keywords:
AgingGanoderma lucidumGut microbiotaKidneyLachnospiraceaeNicotinamide riboside

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