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Related Experiment Video

Updated: Sep 13, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
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Preliminary study of multiple diffusion MRI in defining brain microstructural changes in hypertensive individuals.

Yan Li1, Rui Xiao1, Jie Yang1

  • 1Department of Radiology/Zigong First People's Hospital, Zigong, SiChuan, China.

Brain Research Bulletin
|August 3, 2025
PubMed
Summary

Hypertension damages brain white matter, particularly in untreated patients. Advanced MRI models like NODDI and MAP-MRI, especially extracellular volume fraction (ECVF), detect this injury more sensitively than standard methods.

Keywords:
Diffusion MRIDiffusion tensor imagingHypertensionMean apparent propagator-MRINeurite orientation dispersion and density imagingOrientation dispersion

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Area of Science:

  • Neuroimaging
  • Cardiovascular Research
  • Medical Physics

Background:

  • Hypertension is a prevalent condition associated with increased risk of cerebrovascular complications.
  • Microstructural brain changes, particularly in white matter, are increasingly recognized in hypertensive individuals.
  • Conventional MRI may not fully capture the subtle white matter alterations caused by hypertension.

Purpose of the Study:

  • To employ multiple advanced diffusion MRI models to characterize brain microstructural changes in patients with hypertension.
  • To compare the sensitivity of different diffusion models in detecting white matter abnormalities associated with hypertension.

Main Methods:

  • Utilized diffusion spectrum imaging (DSI) in healthy controls (HC), untreated hypertensive patients, and treated hypertensive patients.
  • Reconstructed DSI data to obtain diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging (NODDI), and mean apparent propagator-MRI (MAP-MRI) parameters.
  • Applied tract-based spatial statistics (TBSS) and appropriate statistical tests to analyze group differences in diffusion parameters.

Main Results:

  • Untreated hypertensive patients showed significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD) and radial diffusivity (RD) compared to HC.
  • Extracellular volume fraction (ECVF) was significantly higher in the white matter of untreated hypertensive patients.
  • Differences in NODDI and MAP-MRI parameters were less pronounced between treated and untreated groups compared to HC and untreated groups.
  • Systolic blood pressure strongly correlated with white matter ECVF.

Conclusions:

  • Advanced diffusion MRI models, specifically NODDI and MAP-MRI derived parameters, are more sensitive in detecting white matter injury in hypertension.
  • Extracellular volume fraction (ECVF) derived from NODDI may serve as a sensitive imaging biomarker for hypertension-related white matter damage.