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Tryptophan promotes sperm hyperactivation in hamsters via 5-hydroxytryptamine biosynthesis within sperm

Issei Suzuki1, Masakatsu Fujinoki2,3, Takao Kamai1

  • 1Department of Urology, Dokkyo Medical University, Tochigi 321-0293, Japan.

The Journal of Reproduction and Development
|August 3, 2025
PubMed
Summary

L-tryptophan enhances sperm hyperactivation by promoting serotonin biosynthesis within sperm. This study confirms sperm produce serotonin, a key factor in sperm motility.

Keywords:
5-HT biosynthesis5-HydroxytryptamineHyperactivationSpermTryptophan

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