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Updated: Sep 13, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Physical function of head and neck cancer survivors in the first year after treatment: an exploratory descriptive
Kelly Coghlan1, Grainne Sheill1, John Ed O Connell2
1Trinity St James's Cancer Institute, Dublin, Ireland; Physiotherapy Department, St James's Hospital, Dublin, Ireland.
Abstract:
The aim of this study was to explore the post-treatment physical function of head and neck cancer survivors (HNCS). A prospective cross-sectional study was conducted. Assessment included physical measures (The Short Physical Performance Battery (SPPB), Strength (30 second Sit to Stand Test and Grip Strength)), patient reported outcome measures (Neck Disability Index (NDI), and the FACT- H&N) and self-reported recovery measures. Participants (n = 30) were 66.7% men. Most had undergone surgery (87%, n = 26) and were less than six months post treatment (80%, n = 25). In total 41% (n = 12) of participants had low physical performance, 72% (n = 21) scored below average strength scores and 67% (n = 20) of participants had neck disability. The FACT H&N found a moderate impairment in quality of life [mean (SD) Trial Outcome Index 60.4 (20.2)] and 24% (n = 7) of participants screened positive for lymphoedema. Seventeen percent (n = 5) have participants reported having a fall in the last 12 months. This study provides descriptive data from a pilot study which may service as a foundation for future research.
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