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Related Experiment Video

Updated: Sep 8, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

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Defining optimal fatty liver index thresholds for MASLD and MetALD using controlled attenuation parameter as

Hideki Fujii¹, Sawako Uchida-Kobayashi², Atsushi Kanamori³

¹Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3, Asahimachi, Abeno, Osaka, 545-8585, Japan.

Journal of Gastroenterology

|August 3, 2025

Summary

This summary is machine-generated.

The fatty liver index (FLI) effectively diagnoses metabolic dysfunction-associated steatotic liver disease (MASLD) and MetALD, with optimal cutoffs varying by sex. These findings aid in accurate diagnosis of liver conditions.

Keywords:

Abdominal ultrasound Alcohol intake Control attenuation parameter Fatty liver index Metabolic dysfunction-associated steatotic liver disease

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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

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Published on: March 24, 2023

Area of Science:

Hepatology
Diagnostic Biomarkers
Metabolic Diseases

Background:

Accurate diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) is crucial.
The fatty liver index (FLI) is a potential biomarker for steatotic liver disease (SLD), but optimal cutoffs for MASLD and MetALD are unclear.

Purpose of the Study:

To determine the optimal cutoff values of the fatty liver index (FLI) for diagnosing MASLD and MetALD.
To investigate potential sex differences in FLI diagnostic performance for these conditions.

Main Methods:

A cross-sectional study of 2512 adults using abdominal ultrasonography (AUS) and vibration-controlled transient elastography (CAP).
Control attenuation parameter (CAP) ≥ 268 dB/m was used as the cutoff for SLD diagnosis.
Area under the receiver operating characteristic curve (AUROC) and Youden index were used to determine optimal FLI cutoff values.

Main Results:

The study identified 956 individuals with SLD, including 648 with MASLD and 231 with MetALD.
Optimal FLI cutoff values for MASLD were 26.7 overall, 26.9 for males, and 19.2 for females.
Optimal FLI cutoff values for MetALD were 34.5 overall, 44.4 for males, and 30.8 for females, indicating higher cutoffs for MetALD and sex-specific differences.

Conclusions:

The optimal FLI cutoff for MetALD is higher than for MASLD.
Significant sex differences exist in the optimal FLI cutoffs for diagnosing both MASLD and MetALD.
These findings refine the use of FLI for diagnosing liver conditions, considering sex-specific thresholds.