Related Experiment Video
Updated: Sep 13, 2025

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Spectroscopic, X-Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular
Nabila A Kheder1, Mostafa E Salem2, Saied M Soliman3
1Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Abstract:
The current study reports a convenient synthetic approach to carboxamide hydrazone hybrids 2a, b. Their chemical structures are investigated using infrared, nuclear magnetic resonance, and mass spectroscopies. In addition, the 3D structure of 2a is explored using single-crystal X-ray analysis, while the important intermolecular contacts are described based on the Hirshfeld analysis. Fukui function, highest occupied molecular orbital-lowest unoccupied molecular orbital, molecular electrostatic potential, and Mulliken charge analysis reveal distinct electrophilic and nucleophilic regions of hydrazone 2a, and support its stability and moderate chemical reactivity. Their antimicrobial potency is also evaluated against six microbial strains. Compound 2b shows significant antibacterial activity against Staphylococcus aureus compared to Gentamicin.
More Related Videos
10:52Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
09:46Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
Related Concept Videos
Spectroscopy of Carboxylic Acid Derivatives
Structures of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the...
Amides to Carboxylic Acids: Hydrolysis
Acid-catalyzed hydrolysis:
Hydrolysis of amides under acidic conditions yields carboxylic acids. Since the reaction occurs slowly, hydrolysis requires the conditions of heat.
The mechanism begins with the protonation of the carbonyl oxygen by the acid catalyst. The protonation makes the amide carbonyl carbon more...
IR and UV–Vis Spectroscopy of Carboxylic Acids
However, the stretching absorptions for the C=O bond vary depending on the structure of carboxylic acids. The C=O bond of the free carboxylic acids shows a higher stretching frequency, 1760 cm−1, while H-bonded carboxylic acids (dimers) exhibit stretching absorptions at a lower frequency,...
Nitriles to Carboxylic Acids: Hydrolysis
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration