Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The microbiome-inflammation-immune axis in oral squamous cell carcinoma: from mechanistic insights to therapeutic perspectives.

Frontiers in immunology·2026
Same author

The Minimal Folding Motif of the Repeat-in-Toxin Domain of Adenylate Cyclase Toxin.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Synthesis, Characterization, and Interfacial Properties of Butynediol Ethoxylate-Based Tetrasiloxanes as Low-Foam Surfactants.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Ionic Crosslinking Improves the Stiffness and Toughness of Protein Hydrogels.

Polymer science & technology (Washington, D.C.)·2025
Same author

Physicochemical Properties of Polyether-Modified Fluorosilicone Surfactants in Ethanol/Water Mixed Solutions.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Intermolecular Misfolding Captured in Parallelly Organized Titin.

Journal of the American Chemical Society·2025
Same journal

Bioinspired Electrostatic-Field Perturbated Sensing for General Material Noncontact Perception.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Engineering Layered Magnetic Hydrogels for Cell Placement via Shear and Magnetic Field-Induced Assembly.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Interfacial Acid Sites-Mediated ZnO-Based Electrocatalysts for Sustainable Dual-Pathway H<sub>2</sub>O<sub>2</sub> Production and Rechargeable Zn-H<sub>2</sub>O<sub>2</sub> Electrochemical Cell.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Zein-Ceria Hybrid Microparticles Enable Long-Term ROS-Scavenging Oxygenation for Osteogenic Microtissues Engineering.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Toward Practical Solid-State Lithium Batteries With High-Nickel Cathodes: An Interface-Centered Perspective.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

A Planarity-Hindrance Co-Balance Strategy to Develop Antiparallel H-Aggregates With Minimal Absorbance Blueshift for Type I Photodynamic Therapy.

Advanced materials (Deerfield Beach, Fla.)·2026
See all related articles

Related Experiment Video

Updated: Sep 13, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.6K

Fully Reshapeable and Recyclable Protein Hydrogels.

Qingyuan Bian1, Hongbin Li1

  • 1Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.

Advanced Materials (Deerfield Beach, Fla.)
|August 4, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed reshapeable and recyclable protein hydrogels using protein folding and reversible disulfide crosslinking. This innovation allows for tunable shape transformations and complete material recycling, addressing waste concerns.

Keywords:
denature crosslinkingprotein folding‐unfoldingprotein hydrogelrecyclingreshapingstiffness

More Related Videos

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

6.9K
Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications
09:19

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

7.3K

Related Experiment Videos

Last Updated: Sep 13, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.6K
Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

6.9K
Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications
09:19

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

7.3K

Area of Science:

  • Materials Science
  • Biotechnology
  • Polymer Chemistry

Background:

  • Traditional hydrogels lack reshapeability and recyclability, leading to waste.
  • Protein hydrogels offer potential but often face similar limitations.
  • Environmental concerns necessitate sustainable and adaptable material solutions.

Purpose of the Study:

  • To engineer protein hydrogels that are fully reshapeable and recyclable.
  • To develop a general strategy integrating protein folding with reversible crosslinking.
  • To create a platform for dynamic and circular protein-based materials.

Main Methods:

  • Utilized protein folding-unfolding transitions triggered by denaturant concentration.
  • Integrated reversible disulfide crosslinking for dynamic network formation.
  • Demonstrated consecutive shape transformations and complete protein recovery and reuse.

Main Results:

  • Achieved reversible reshaping of protein hydrogels across 1D, 2D, and 3D geometries.
  • Demonstrated tunable, reproducible, and chemically erasable shape transformations.
  • Showcased full recyclability and remolding of hydrogels without loss of mechanical properties.

Conclusions:

  • Developed a robust strategy for creating dynamic and circular protein hydrogels.
  • Addressed limitations of traditional hydrogels regarding reshapeability and recyclability.
  • Established a platform for next-generation protein-based materials with enhanced sustainability.