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Updated: Apr 27, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
A New Dimension in Tumor Heterogeneity: Intratumoral Bacteria Impact Multifocal Hepatocellular Carcinoma Development
Amiran K Dzutsev1, Giorgio Trinchieri1
1Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
None:
Lu and colleagues identified profound microbial heterogeneity across individual tumor nodules in multifocal hepatocellular carcinoma, revealing that specific bacterial consortia enrich in metastatic clones and drive epithelial-mesenchymal transition and immune suppression. Their study places the intratumoral microbiome alongside genomic and transcriptomic diversity as a key modulator of intrahepatic tumor evolution. See related article by Lu et al., p. 1630.
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