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The effect of thyroid disorders on the cutaneous manifestations in patients with chronic kidney disease

Zewei Chen1, Weifeng Hu2, Erwen Kou3

  • 1Department of Nephrology, The First Navy Hospital of Southern Theater Command, Zhanjiang, China.

Renal Failure
|August 4, 2025
PubMed

Insights

Thyroid disorders significantly impact skin conditions in chronic kidney disease (CKD) patients. Understanding these connections aids in managing challenging dermatological issues in CKD.

Area of Science:

  • Nephrology
  • Endocrinology
  • Dermatology

Background:

  • Cutaneous manifestations in chronic kidney disease (CKD) pose significant clinical challenges.
  • The etiology and pathophysiology of CKD-related skin issues are not fully understood.
  • Thyroid disorders are common in CKD patients but often overlooked.

Purpose of the Study:

  • To systematically review the impact of thyroid disorders on CKD-related cutaneous manifestations.
  • To explore the mechanisms by which thyroid disorders influence these skin conditions.
  • To identify potential therapeutic targets for managing these dermatological complications.

Main Methods:

  • Comprehensive literature search for studies on thyroid disorders and CKD-related skin issues.
  • Synthesis of current knowledge regarding the association and underlying mechanisms.
  • Analysis of existing research to identify knowledge gaps and future directions.

Main Results:

  • Thyroid disorders are implicated in modulating and potentially causing CKD-related skin problems.
  • Evidence suggests a critical role for thyroid function in the presentation of dermatological complications in CKD.
  • A lack of systematic reviews hinders a complete understanding of this relationship.

Conclusions:

  • Thyroid disorders are a key, yet under-recognized, factor in CKD-related dermatological issues.
  • Further research into the mechanisms is crucial for developing effective management strategies.
  • This review enhances understanding and highlights the need for novel therapeutic targets.
Keywords:
Cutaneous manifestationchronic kidney diseaseendocrine dysfunctionpathophysiologythyroid disorder

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