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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
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Does SOX-2 expression have a prognostic value in triple-negative breast cancer?
Ismail Guzelis1, Betul Bolat Kucukzeybek2, Merve Gursoy3
1Pathology Department, Izmir Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkey.
Summary
SRY-box transcription factor 2 (SOX-2) expression was evaluated in triple-negative breast cancer (TNBC). SOX-2 was not significantly associated with survival outcomes in this cohort, suggesting larger studies are needed.
Area of Science:
- Oncology
- Cancer Stem Cell Biology
Background:
- Triple-negative breast cancer (TNBC) is an aggressive subtype.
- Cancer stem cells (CSCs) drive tumor initiation.
- SOX-2 is a marker for CSCs involved in tumorigenesis.
Purpose of the Study:
- To investigate the association between SOX-2 expression and histopathological features in TNBC patients.
- To evaluate the correlation of SOX-2 expression with clinical outcomes, including overall and disease-free survival.
Main Methods:
- Analysis of 95 TNBC cases.
- Immunohistochemical staining for SOX-2 using an in vitro diagnostic antibody on tumor slides.
- Validated automated staining and H-score for SOX-2 expression quantification (H-score ≥ 1).
Main Results:
- SOX-2 expression was detected in 30.5% of TNBC cases.
- No significant association was found between SOX-2 expression and overall or disease-free survival at a median follow-up of 76 months.
- While cases with SOX-2 H-score ≥ 3 showed trends towards lower survival, these differences were not statistically significant.
Conclusions:
- The current study did not establish a significant prognostic role for SOX-2 in TNBC.
- Larger patient cohorts and standardized methodologies are recommended to clarify the prognostic significance of SOX-2 in TNBC.
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