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A case of ICIs-associated arthritis caused by Toripalimab initially presenting as oedema in both lower limbs

Jie-Ling Zhang1, Hao Yang2, Zhi-Li Zhou3

  • 1Department of Radiation Oncology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China.

Journal of Chemotherapy (Florence, Italy)
|August 4, 2025
PubMed

The use of immune checkpoint inhibitors (ICIs) has offered new hope for patients with malignant tumours; however, it is essential to acknowledge their potential toxic side effects. Among these, ICIs-associated arthritis (IA) is not uncommon but non-specific and lacks diagnostic criteria. In this case, a patient with advanced colon cancer developed IA following treatment with Toripalimab. Notably, the condition improved after the administration of steroids, and the tumour remains well-controlled. This case report significantly contributes to enhancing clinicians' understanding of IA.

Keywords:
ICIs-associated arthritisToripalimabcolon cancerirAEsside effect

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