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Updated: Sep 13, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Mendelian Randomization Analysis Reveals Causal Associations Between Beverages and Irritable Bowel Syndrome: Alcohol,
Ruiqing Yuan1,2, Yajing Zhou1, Yujie Ren1
1Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Abstract:
Observational studies have suggested that beverage intake could have potential connections with irritable bowel syndrome (IBS). However, the association patterns and the underlying mechanisms remain unknown. The study identified potential causal relationships between alcohol intake and IBS, showing positive associations for alcohol intake frequency (odds ratio = 1.18, 95% confidence interval = 1.09-1.26; p < 0.001). Psychiatric disorders were found to play mediative roles with mediation effects of 25.22%, 45.77%, and 12.10% for depression (broad), major depression disease, and attention deficit hyperactivity disorder, respectively. These findings suggest that reducing alcohol intake may help prevent IBS, especially in individuals with psychiatric conditions.
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