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Nasopharyngeal Staphylococcus aureus Isolation and Bacterial Culture Profiles in COVID-19 Patients: A Comparative
Burcu Vural Camalan1, Naciye Badir2, Sumeyra Doluoglu1
1Department of Otorhinolaryngology Head and Neck Surgery, University of Health Sciences Ankara Etlik City Hospital, Ankara, TUR.
Purpose:
This exploratory study aimed to determine the nasopharyngeal carriage rate of Staphylococcus aureus and to characterize the distribution of other culturable bacterial species in patients with COVID-19. Additionally, we assessed whether bacterial growth patterns differed between patients with and without lung involvement.
Methods:
Nasopharyngeal samples were collected from COVID-19 patients with and without lung involvement, as assessed by thoracic CT scans. The study also included PCR-negative control patients. Sampling occurred between January and March 2021 at a state hospital outpatient clinic. A total of 65 participants were included in the study: 51 (78.5%) tested positive for COVID-19, of whom 25 (49.0%) had lung involvement and 26 (51.0%) did not. The remaining 14 (21.5%) served as PCR-negative controls.
Results:
S. aureus was isolated in 11 (21.6%) of COVID-19-positive patients and 5 (35.7%) of controls. Among COVID-19 patients, the isolation rate was 6 (24.0%) in those with lung involvement and 5 (19.2%) in those without. No statistically significant differences were observed in S. aureus carriage or in the overall bacterial profiles across the groups.
Conclusion:
Nasopharyngeal S. aureus colonization and bacterial distribution showed no significant association with COVID-19 status or lung involvement. Although colonization is common, its clinical relevance in early-stage COVID-19 remains unclear and warrants further study.
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