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A Propensity-Matched Cohort Study Assessing Neuropathy in Patients With Leukocytoclastic Vasculitis
Kritin K Verma1, Sezim Minbaeva1, Orson T Robertson1
1School of Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.
Cureus
|August 4, 2025
Summary
Leukocytoclastic vasculitis (LCV) patients show a 20.9% increased risk of developing neuropathy. This study highlights a significant association between LCV and neurological complications, emphasizing the need for monitoring.
Area of Science:
- Rheumatology
- Neurology
- Epidemiology
Background:
- Leukocytoclastic vasculitis (LCV) is a small-vessel vasculitis primarily affecting the skin.
- Systemic involvement of LCV, including neuropathy, is increasingly recognized.
- The association between LCV and neuropathy risk requires further investigation.
Purpose of the Study:
- To investigate the potential relationship between leukocytoclastic vasculitis (LCV) and neuropathy.
- To assess if LCV patients have a higher risk of developing neuropathy compared to a matched control group.
Main Methods:
- Retrospective cohort study using the TriNetX database.
- 4,519 LCV patients were matched with 4,519 controls based on age, sex, and race.
- Neuropathy identified using ICD-10-CM code G62.9; relative risk (RR) calculated.
Main Results:
- 5.4% of LCV patients developed neuropathy versus 4.6% in controls.
- LCV patients had a statistically significant 20.9% higher risk of neuropathy (RR = 1.209, p = 0.0396).
- A 95% confidence interval of 1.009-1.448 was observed.
Conclusions:
- This study provides evidence for an association between LCV and an increased risk of neuropathy.
- LCV may contribute to neuropathy development through vasculitic damage to nerve blood supply.
- Vigilant monitoring for neurological symptoms in LCV patients is crucial.
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