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Biomolecule-functionalized dental implant surfaces: Towards augmenting soft tissue integration.
Ghazal Shineh1,2, Leila Mamizadeh Janghour1, Yiyun Xia2,3
1School of Biomedical Engineering, University of Sydney, Sydney, New South Wales 2006, Australia.
Bioactive Materials
|August 4, 2025
Summary
Biofunctionalization actively enhances dental implant success by promoting peri-implant soft tissue integration (PSTI). This strategy engineers implant surfaces to improve microbial defense and clinical outcomes.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Tissue Engineering
Background:
- Peri-implant soft tissue integration (PSTI) is crucial for dental implant longevity, preventing inflammation and microbial invasion.
- Passive surface modifications alone are insufficient for rapid and robust PSTI.
- Active strategies are needed to engineer implant surfaces for enhanced biological interaction.
Purpose of the Study:
- To review and analyze advanced biofunctionalization strategies for dental implants.
- To explore the mechanisms of biomolecule-implant interactions in promoting PSTI.
- To provide a framework for developing next-generation implant technologies.
Main Methods:
- Evaluation of biomolecule incorporation techniques (physical and covalent attachment).
- Analysis of functionalization approaches using proteins, peptides, and cells.
- Review of strategies to regulate immune responses and enhance antimicrobial defense.
Main Results:
- Biofunctionalization offers a transformative approach to implant surface engineering.
- Different attachment methods provide distinct advantages in stability, efficiency, and scalability.
- Bioactive molecules and cells can be utilized to mimic natural biological interactions.
Conclusions:
- Bioengineered implant surfaces can actively promote PSTI, leading to improved clinical outcomes.
- Understanding biomolecule-implant interactions is key to designing effective implant surfaces.
- Next-generation dental implant technologies hold significant potential for clinical translation.
Keywords:
BiofunctionalizationBiomolecule-implant interactionsDental implantsSoft tissue integrationSurface bioengineering
