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Updated: Sep 13, 2025

Diffusion Imaging in the Rat Cervical Spinal Cord

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Multi-institution longitudinal apparent diffusion coefficient measurements in a diffusion weighted imaging phantom at

Chris Moore^1,2, Charlotte Bull³, Angela Darekar⁴

¹Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK.

Physics and Imaging in Radiation Oncology

|August 4, 2025

Summary

This study validated apparent diffusion coefficient (ADC) measurements using a novel phantom, showing good accuracy and repeatability for multi-institution cancer biomarker studies. Simplified quality assurance is now feasible for longitudinal imaging.

Keywords:

Imaging biomarkers Multi-centre longitudinal QA QA Quantitative apparent diffusion coefficient Technical validation

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Last Updated: Sep 13, 2025

Diffusion Imaging in the Rat Cervical Spinal Cord

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Published on: April 7, 2015

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Area of Science:

Biomedical Imaging
Quantitative MRI
Biomarker Development

Background:

Apparent Diffusion Coefficient (ADC) is a key biomarker in cancer research.
Technical validation is crucial for multi-institutional studies.
Standardized quality assurance protocols are needed for reliable ADC measurements.

Purpose of the Study:

To technically validate ADC measurements across multiple institutions.
To evaluate ADC accuracy, repeatability, and reproducibility using a room-temperature phantom.
To assess the feasibility of transferring diffusion-weighted imaging (DWI) sequences between scanners.

Main Methods:

Utilized a traveling room-temperature DWI phantom across six scanners at four UK institutions over 18 months.
Calculated ADC bias, intra-scanner repeatability, and inter-scanner reproducibility according to QIBA DWI profiles.
Employed an MR-readable thermometer for simplified ADC measurements without ice-water setup.

Main Results:

Mean ADC bias was <0.01 × 10⁻³ mm²s⁻¹ (0.81%).
Mean isocenter ADC error estimate was 1.43%, with average short-term repeatability <0.01 × 10⁻³ mm²s⁻¹ (1%).
Reproducibility was 0.07 × 10⁻³ mm²s⁻¹ (9%).

Conclusions:

Demonstrated good ADC accuracy, repeatability, and reproducibility.
Confirmed the feasibility of transferring diagnostic DWI sequences between scanners from the same manufacturer.
Showcased the potential for assessing ADC in multi-institution longitudinal studies with minimal quality control.