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Related Concept Videos

Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

23
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
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Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
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Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

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AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
28
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

40
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
40
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

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Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
27
Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Sep 13, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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An Orthotopic Murine Model of Human Prostate Cancer Metastasis

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Obstructive Ureteral Metastasis From Prostate Cancer.

Ahmad Al-Bitar1, Alaa Senjab1, Zeina Alhamwy1

  • 1Faculty of Medicine Damascus University Damascus Syrian Arab Republic.

Clinical Case Reports
|August 4, 2025
PubMed
Summary

Ureteral metastasis from prostate cancer is rare, often mimicking stones. This case highlights the diagnostic challenge and need for high clinical suspicion in obstructive uropathy patients.

Keywords:
hydronephrosismetastasisprostate cancerureter stonesureteral metastasisureteral obstruction

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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
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Area of Science:

  • Urology
  • Oncology

Background:

  • Prostate cancer is a common male malignancy.
  • Metastases typically affect lymph nodes, bones, and liver.
  • Ureteral metastasis causing obstruction is exceptionally rare.

Purpose of the Study:

  • To report a rare case of ureteral metastasis from prostate cancer.
  • To emphasize the diagnostic challenges and management of this condition.

Main Methods:

  • Case report of an 82-year-old male with prostate adenocarcinoma.
  • Diagnostic workup included imaging, ureteroscopy, and biopsy.
  • Management involved nephroureterectomy and postoperative surveillance.

Main Results:

  • Ureteroscopy revealed obstructing ureteral tumors, confirmed as prostatic adenocarcinoma.
  • Histopathology showed extensive ureteral involvement with vascular and perineural invasion.
  • Postoperative PET-CT confirmed no distant metastasis.

Conclusions:

  • Ureteral metastasis from prostate cancer can mimic benign conditions like ureteral stones.
  • High clinical suspicion is vital for early diagnosis in patients with obstructive uropathy.
  • Prompt intervention and long-term surveillance are crucial for managing aggressive ureteral metastasis.