JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Determining the Impact of Histology on the Incidence, Pattern, and Timing of Recurrences in Patients with Renal Cell Carcinoma: A Pooled Analysis from the SORCE and ASSURE Trials

  • 0MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, London, UK.
European Urology Open Science +

|

August 4, 2025

|

August 4, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Histological subtype of renal cell carcinoma (RCC) impacts relapse timing and patterns. Papillary RCC and sarcomatoid RCC patients experiencing abdominal recurrence have poorer outcomes, suggesting tailored surveillance strategies. Clear-cell RCC and chromophobe RCC show different relapse characteristics.

Area Of Science

  • Urology
  • Oncology
  • Nephrology

Background

  • Outcomes for intermediate- and high-risk renal cell carcinoma (RCC) based on histological subtype are not well-defined.
  • Histology is crucial for predicting survival and informing surveillance after nephrectomy for RCC.

Purpose Of The Study

  • To determine the prognostic value of RCC histology in predicting survival.
  • To inform surveillance strategies by analyzing patterns of first recurrence based on RCC subtype.

Main Methods

  • Pooled data from two phase 3 trials (SORCE and ASSURE) involving 3542 patients with RCC.
  • Classified patients into clear-cell RCC (ccRCC), papillary RCC (pRCC), chromophobe RCC (chRCC), and sarcomatoid RCC (sRCC).
  • Analyzed relapse rates, time to relapse (TTR), and first relapse sites using multivariable Cox regression models.

Main Results

  • Papillary RCC (pRCC) and clear-cell RCC (ccRCC) showed similar overall survival.
  • Median time to relapse (TTR) was significantly shorter for pRCC (1.34 yr) compared to ccRCC (1.78 yr).
  • Sarcomatoid RCC (sRCC) had the shortest TTR (0.74 yr), while chromophobe RCC (chRCC) had the longest (2.72 yr). Abdominal recurrence in sRCC and pRCC was associated with poorer survival.

Conclusions

  • Intermediate and high-risk pRCC patients relapse earlier than ccRCC patients.
  • Abdominal recurrence in pRCC and sRCC indicates poor prognosis, suggesting enhanced abdominal imaging for early detection.
  • chRCC has a favorable prognosis, potentially allowing for delayed image-based surveillance.

Keywords: