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A strain-programmed lignin-based Janus patch for rapid healing of postoperative rectal wounds
Yi Yu1, Jiaxin Pan1,2, Jianbo Zhang3
1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
A novel Janus patch accelerates rectal wound healing by combating infection and inflammation. This medical innovation shows promise for improving recovery after hemorrhoidectomy and other intestinal surgeries.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Surgical Innovation
Background:
- Post-hemorrhoidectomy patients suffer pain, bleeding, and delayed healing due to fecal contamination.
- Recurrent contamination exacerbates wound irritation and complicates recovery.
Purpose of the Study:
- To develop a multifunctional Janus patch for accelerated rectal wound repair.
- To address challenges in postoperative wound management after hemorrhoidectomy.
Main Methods:
- Developed a strain-programmed, lignin-based multifunctional Janus patch (S-SFR@AGL).
- The patch combines anti-biofouling silicone rubber with antibacterial, antioxidant, and hemostatic lignin hydrogel.
- Tested the patch on infected rat rectal wounds.
Main Results:
- The Janus patch effectively cleared bacteria and reduced inflammation in infected rat rectal wounds within one week.
- Modulated the wound's mechanical microenvironment, promoting muscle contraction and epithelial cell differentiation.
- Achieved significant acceleration in wound healing.
Conclusions:
- The developed Janus patch demonstrates potential for shortening intestinal wound healing time.
- This innovation could optimize postoperative management for patients undergoing intestinal lesion resection.
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