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Related Concept Videos

Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart, a...
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

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Rotator Cuff Repair With Bone Marrow Stimulation Versus Rotator Cuff Repair With Patch Augmentation: A Systematic Review.

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Platelet Concentration Does Not Influence Clinical Efficacy and Retear Rates of Rotator Cuff Repair With Platelet-Rich Plasma: A Systematic Review and Meta-analysis With Meta-Regression.

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Related Experiment Video

Updated: Jun 20, 2026

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
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Rotator Cuff Repair With Platelet-Rich Plasma Is Associated With Lower Retear Rates When Compared With Rotator Cuff

Joseph J Lim1, Cleveland McCarty1, John W Belk1

  • 1Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Orthopaedic Journal of Sports Medicine
|August 4, 2025
PubMed
Summary
This summary is machine-generated.

Platelet-rich plasma (PRP) may reduce retear rates in rotator cuff repair (RCR) compared to patch augmentation (PA). Both treatments offer similar functional improvements, but PRP shows a statistically significant decrease in retears.

Keywords:
patchplatelet-rich plasmarotator cuff repairshoulder

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Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Rotator cuff repair (RCR) often utilizes adjuncts like platelet-rich plasma (PRP) and patch augmentation (PA) to enhance healing and repair strength.
  • These methods aim to improve patient outcomes following surgical repair of the rotator cuff.

Purpose of the Study:

  • To systematically review and compare the clinical efficacy of RCR augmented with PA versus RCR augmented with PRP.
  • To evaluate differences in patient-reported outcomes, range of motion, and retear rates between the two augmentation techniques.

Main Methods:

  • A systematic literature review was conducted using PubMed, Cochrane Library, and Embase databases.
  • Included studies were Level 1 or 2 evidence comparing RCR with PRP or PA.
  • Outcomes assessed included pain scores, functional scores (Constant-Murley, ASE, UCLA), range of motion, and retear rates.

Main Results:

  • The review included 27 studies with 342 patients in the PA group and 547 in the PRP group.
  • No significant differences were found in patient-reported outcomes or range of motion between RCR with PRP and RCR with PA.
  • However, RCR with PRP showed significantly lower retear rates (13.1%) compared to RCR with PA (18.4%).

Conclusions:

  • Platelet-rich plasma (PRP) augmentation in rotator cuff repair may lead to lower retear rates compared to patch augmentation (PA).
  • Both PRP and PA provide comparable improvements in patient-reported and functional outcomes.
  • Further randomized controlled trials are warranted to directly compare these two adjuncts in RCR.