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Updated: Sep 13, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Early presentation of Hirschsprung's disease with initial meconium passage: A diagnostic challenge
1Department of Pediatrics, Joan C. Edwards Marshall University School of Medicine, Huntington, WV, USA.
Abstract:
Hirschsprung's disease is a congenital condition characterized by an absence of enteric ganglionic cells. In this paper, we report a case of an 8-day-old male infant presenting with a history of constipation and progressive abdominal distension. Meconium had been passed in the newborn nursery. No stools were passed after 4 days of age, and the last one had required rectal stimulation. We emphasize the diagnostic challenges associated with Hirschsprung's disease in neonates who initially pass meconium. Timely recognition and surgical intervention achieved a favorable outcome.
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