Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

33
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
33
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

40
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
40
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

35
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
35
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

25
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
25
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

46
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
46
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

34
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
34

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutrophils as chameleons of tissue inflammation and host-pathogen interactions.

Blood·2026
Same author

Dual activation of NLRP3 and pyrin inflammasomes mediates host responses to the human fungal pathogen Coccidioides.

Nature communications·2026
Same author

Multisite evaluation of automated electronic case report form data entry from electronic health records.

Journal of biomedical informatics·2026
Same author

Clinical characteristics, type 2 comorbidities, and treatment responses in pediatric and adult chronic spontaneous urticaria: A multicenter retrospective cohort study.

Allergy and asthma proceedings·2026
Same authorSame journal

Atopic Comorbidities Associated With Chronic Spontaneous Urticaria: A Case-Control Analysis of the All of Us Research Program.

JEADV clinical practice·2026
Same author

Investigating the Use of the Fast Health Care Interoperability Resources (FHIR) Standard to Support Data Activities Across the PCORnet® Infrastructure: Lessons Learned From the FHIR Pilots of the Coordinating Center for PCORnet®.

Medical care·2026

Related Experiment Video

Updated: Sep 13, 2025

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
08:25

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

9.2K

Pyoderma gangrenosum associated with major adverse cardiovascular events.

Nana Ama Adjei-Frimpong1, Francesco Delacqua2, Ben A Croker3

  • 1Department of Dermatology, University of California San Diego, San Diego, CA, U.S.A.

JEADV Clinical Practice
|August 4, 2025
PubMed
Summary

Pyoderma gangrenosum (PG) is linked to a higher risk of major adverse cardiovascular events (MACE). This study confirms this association in a US population, emphasizing the need for cardiovascular screening in PG patients.

Keywords:
all of usmajor adverse cardiovascular eventspyoderma gangrenosum

More Related Videos

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K
Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.1K

Related Experiment Videos

Last Updated: Sep 13, 2025

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
08:25

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

9.2K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K
Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.1K

Area of Science:

  • Cardiology
  • Dermatology
  • Epidemiology

Background:

  • Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis causing painful ulcers.
  • Previous studies suggested a link between PG and major adverse cardiovascular events (MACE), but lacked robust controls and US data.
  • This research addresses these limitations by utilizing a US-based, diverse population dataset.

Purpose of the Study:

  • To investigate the association between pyoderma gangrenosum (PG) and major adverse cardiovascular events (MACE) in a US population.
  • To leverage the All of Us (AoU) database for a comprehensive analysis.
  • To provide evidence for improved cardiovascular risk assessment in PG patients.

Main Methods:

  • A nested case-control study was conducted using the All of Us (AoU) database (May 2018 - March 2025).
  • Pyoderma gangrenosum (PG) cases were identified using SNOMED codes and matched 4:1 to controls.
  • Logistic regression analysis assessed the association between PG and MACE, adjusting for key comorbidities.

Main Results:

  • The study identified 579 cases of pyoderma gangrenosum (PG).
  • A significant association was found between PG and major adverse cardiovascular events (MACE) (OR, 2.19; 95% CI, 1.47-3.27; p<.001).
  • This association remained significant after multivariable adjustment.

Conclusions:

  • Pyoderma gangrenosum (PG) is independently associated with increased odds of major adverse cardiovascular events (MACE) in a US cohort.
  • These findings underscore the necessity of cardiovascular screening and proactive risk management for patients with PG.
  • Further research into the underlying pathophysiological mechanisms is warranted to guide targeted treatment strategies.