Comprehensive Genetic Analysis of Central Nervous System Involvement in Mycosis Fungoides: A Case Report

The incidence of central nervous system (CNS) involvement in mycosis fungoides (MF) is low. Here, we report a case of CNS involvement 3 years after MF diagnosis, comparing genetic alterations identified by amplicon-based targeted sequencing between a primary skin sample and a brain tissue sample. TNFAIP3 mutation, MYC gain, CDKN2A/B loss, and SOCS1 loss were concordantly detected, while MYC mutation was only found in the brain sample. This is the first report of a comprehensive genetic analysis of CNS involvement in MF, providing novel insights into genetic factors potentially associated with CNS involvement.