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Updated: Sep 12, 2025
07:54
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
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Sarcopenia and Pleural Mesothelioma: The Current Knowledge.
Nikolaos D Karakousis1, Konstantinos I Gourgoulianis1, Nikolaos Papanas2
1Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.
Muscles (Basel, Switzerland)
|August 4, 2025
Summary
Sarcopenia, a loss of muscle mass, is linked to poorer survival and lower activity in pleural mesothelioma (PM) patients. Addressing sarcopenia may improve outcomes for those with this asbestos-related cancer.
Area of Science:
- Oncology
- Geriatrics
- Pulmonology
Background:
- Pleural mesothelioma (PM) is a serious cancer with poor prognosis.
- Sarcopenia, characterized by muscle mass and strength loss, is a global health concern linked to adverse outcomes.
- Understanding the relationship between sarcopenia and PM is crucial for patient management.
Purpose of the Study:
- To review the current literature on the association between sarcopenia and pleural mesothelioma.
- To explore the impact of sarcopenia on survival, activity levels, and quality of life in PM patients.
Main Methods:
- Literature review of existing studies on sarcopenia and pleural mesothelioma.
- Analysis of data concerning patient survival, activity, malnutrition, and quality of life.
Main Results:
- Muscle loss in PM patients correlates with reduced survival and activity.
- PM patients exhibit higher rates of pre-sarcopenia and malnutrition, impacting quality of life.
- Sarcopenia, both pre- and post-operatively, is associated with poorer survival and increased adverse outcomes in surgically treated PM patients.
Conclusions:
- Sarcopenia is a significant factor associated with adverse outcomes in pleural mesothelioma.
- Further research is required to validate the clinical implications of sarcopenia in PM management.
- Early identification and intervention for sarcopenia may improve patient prognosis.
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