Related Experiment Video

Updated: Jul 10, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.5K

Up-to-date review on concomitant mitral transcatheter edge-to-edge repair and left atrial appendage occlusion

Graeme Prosperi-Porta1, Abdullah Al-Abcha2, Trevor Simard2

  • 1Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada.

Future Cardiology
|August 4, 2025
PubMed

Insights

Concomitant left atrial appendage occlusion (LAAO) during mitral valve transcatheter edge-to-edge repair (M-TEER) may reduce risks for atrial fibrillation patients. Further research is needed to confirm the safety and feasibility of this combined procedure.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Atrial fibrillation is common in patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER).
  • Oral anticoagulation is standard for stroke prevention in atrial fibrillation.
  • Left atrial appendage occlusion (LAAO) offers an alternative to oral anticoagulation, reducing long-term stroke and bleeding risks but carrying procedural risks.

Purpose of the Study:

  • To review the current literature on concomitant M-TEER and LAAO.
  • To discuss practical procedural considerations for combined interventions.
  • To identify unmet research questions regarding the safety and feasibility of simultaneous M-TEER and LAAO.

Main Methods:

  • Narrative review of existing studies and literature.
  • Analysis of shared procedural characteristics between M-TEER and LAAO.
  • Evaluation of potential benefits and risks of combined procedures.

Main Results:

  • M-TEER and LAAO share procedural similarities, suggesting potential for combined intervention.
  • Concomitant procedures may reduce cumulative peri-procedural risks, anesthetic exposure, and hospital visits.
  • Limited data currently exists on the safety and feasibility of performing M-TEER and LAAO together.

Conclusions:

  • Performing LAAO concurrently with M-TEER is a potentially attractive strategy for select atrial fibrillation patients.
  • Further research is essential to establish the safety, efficacy, and optimal implementation of concomitant M-TEER and LAAO.
  • Addressing current research gaps will facilitate wider adoption of this combined interventional approach.

Keywords:
Mitral regurgitationatrial fibrillationconcomitant interventionleft atrial appendage occlusiontranscatheter edge-to-edge repair

More Related Videos

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.8K
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.0K

Related Concept Videos

Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...