Push-Pull Electronic Effect and D-Band Center Bi-Modulated Bio-Heterojunction Enzyme Enables All-Stage Infected Wound...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Catalysis

Background:

• Pathogenic infections present a global health challenge, requiring advanced antibacterial methods.
• Current antibacterial strategies face limitations due to challenges in reactant adsorption and intermediate desorption.
• Developing novel disinfection pathways is crucial for effective antimicrobial treatments.

Purpose of the Study:

• To propose and construct a FeMoS4/MXene bio-heterojunction enzyme (FM BioHJzyme) for enhanced antibacterial applications.
• To investigate the mechanism of FM BioHJzyme in generating reactive oxygen species (ROS) under near-infrared (NIR) light.
• To evaluate the therapeutic efficacy of FM BioHJzyme in a bacterial infection model.

Main Methods:

• Fabrication of FeMoS4/MXene bio-heterojunction enzyme (FM BioHJzyme).
• Investigation of electron-hole separation and reactant polarization under NIR irradiation.
• Assessment of Fe active sites and intermediate adsorption energy.
• Evaluation of antibacterial activity and wound healing in an S. aureus infection model.

Main Results:

• FM BioHJzyme demonstrated efficient electron-hole separation and ROS generation under NIR light.
• An electronic push-pull effect facilitated polarization of reactants towards Fe active centers.
• Enhanced electron density and a downshifted Fe d-band center reduced intermediate adsorption energy.
• FM BioHJzyme showed significant antibacterial efficiency and promoted wound healing via collagen deposition and angiogenesis.

Conclusions:

• The FM BioHJzyme platform offers a mechanism-guided design for catalytic antibacterial applications.
• NIR-triggered FM BioHJzyme provides an effective strategy for combating pathogenic infections.
• This approach facilitates both bacterial clearance and subsequent tissue regeneration, presenting a sustainable therapeutic solution.