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Does Sestrin-1 Mitigate Cardiovascular Risks in Radiographic Axial Spondyloarthritis?
Selman Parlak1, Ahmet Taha Sahin2, Ahmet Lütfü Sertdemir3
1Department of Rheumatology, Beyhekim Training and Research Hospital, Konya, Türkiye.
Archives of Rheumatology
|August 4, 2025
Summary
Patients with radiographic axial spondyloarthritis (r-axSpA) have lower Sestrin-1 levels, linked to increased cardiovascular risk and impaired heart function. Reduced Sestrin-1 may worsen inflammation and oxidative stress in r-axSpA patients.
Area of Science:
- Rheumatology and Cardiology
- Biochemistry and Molecular Biology
Background:
- Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory condition associated with elevated cardiovascular (CV) risk.
- Persistent inflammation in r-axSpA contributes to this increased CV risk.
- Sestrin-1, a protein with antioxidant and anti-inflammatory roles, is crucial for cardiovascular protection.
Purpose of the Study:
- To investigate the association between Sestrin-1 levels and cardiovascular markers in r-axSpA patients.
- To evaluate echocardiographic findings and their relationship with Sestrin-1 in r-axSpA.
- To explore Sestrin-1's role in the cardiovascular complications of r-axSpA.
Main Methods:
- A controlled study involving 48 r-axSpA patients and 48 healthy controls.
- Measurement of Sestrin-1 levels using ELISA and assessment of carotid intima-media thickness (CIMT) via ultrasound.
- Collection of demographic, biochemical (including CRP and ESR), and echocardiographic data.
Main Results:
- r-axSpA patients showed significantly lower Sestrin-1 levels compared to controls (P=.003).
- Sestrin-1 levels negatively correlated with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).
- r-axSpA patients exhibited increased CIMT, reduced right ventricular systolic motion (RVSM), and lower tricuspid annular plane systolic excursion (TAPSE).
Conclusions:
- r-axSpA patients present with diminished Sestrin-1 levels and subclinical cardiovascular changes, including increased CIMT and impaired right ventricular function.
- Reduced Sestrin-1 may contribute to heightened oxidative stress and inflammation, exacerbating cardiovascular risk in r-axSpA.
- Further research is warranted to assess Sestrin-1's potential as a biomarker for CV complications in r-axSpA.
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