Jove
Visualize
Contact Us

Related Experiment Videos

A back-to-back zig-zag model for higher order chromatin structure.

L A Burgoyne

    Cytobios
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rapid preparation of cyanobacterial DNA for real-time PCR analysis.

    Letters in applied microbiology·2007
    Same author

    Collecting, archiving and processing DNA from wildlife samples using FTA databasing paper.

    BMC ecology·2004
    Same author

    Photosensitizer initiated attacks on DNA under dry conditions and their inhibition: a DNA archiving issue.

    Journal of photochemistry and photobiology. B, Biology·2001
    Same author

    Species identity: conserved inverted LINE repeat clusters (ILRC) in the vertebrate genome as indicators of population boundaries.

    Gene·2001
    Same author

    Reverse transcription of an RNA genome from databasing paper (FTA(R)).

    Biotechnology and applied biochemistry·2000
    Same author

    The mechanisms of pyknosis: hypercondensation and death.

    Experimental cell research·1999
    Same journal

    Behaviour of fibroblastic cells cultured in collagen I using the sandwich technique.

    Cytobios·2001
    Same journal

    Effect of prenatal lead toxicity on surface ultrastructural features, elemental composition and infrared absorption characteristics of the skin of albino mice.

    Cytobios·2001
    Same journal

    Disturbances in cellular features and elemental homeostasis in the integument of a freshwater fish Channa punctatus (Bloch) in relation to hydrogen ion concentration of polluted water.

    Cytobios·2001
    Same journal

    Molecular characterization of hereditary persistence of foetal haemoglobin mutation by restriction fragment length polymorphism mapping.

    Cytobios·2001
    Same journal

    DNA topoisomerases in cancer chemotherapy: basic and applied aspects.

    Cytobios·2001
    Same journal

    Spermiogenesis in Melanophryniscus cambaraensis (Amphibia, Anura, Bufonidae): ultrastructural and cytochemical studies of carbohydrates using lectins.

    Cytobios·2001
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    A new model proposes hair-pin loops, not coiling, for higher-order chromatin structure. This DNA loop model explains how base sequences control folding and may facilitate homologous chromosome alignment during synapse.

    Area of Science:

    • Molecular Biology
    • Genetics
    • Cell Biology

    Background:

    • Chromatin structure is organized hierarchically above the DNA double helix.
    • Existing models for higher-order chromatin folding, such as coiling, face challenges in explaining observed evidence.

    Purpose of the Study:

    • To examine evidence for chromatin structure beyond the 'zig-zag' level.
    • To propose an alternative model for higher-order chromatin folding.

    Main Methods:

    • Analysis of existing evidence regarding chromatin higher-order structure.
    • Development of a theoretical model based on structural interpretations.

    Main Results:

    • A 'hair-pin' loop model is proposed as a better fit for current evidence than coiling models.

    Related Experiment Videos

  • This loop model provides a mechanism for DNA base sequences to influence chromatin folding.
  • The model suggests a simple way homologous DNA filaments align during synapse.

    • Conclusions:

    • The proposed hair-pin loop model offers a compelling explanation for higher-order chromatin organization.
    • This model has implications for understanding DNA sequence-directed chromatin folding.
    • The model provides insights into the mechanism of homologous alignment in chromatin structure.