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Updated: May 6, 2026

Automated Sholl Analysis of Digitized Neuronal Morphology at Multiple Scales
Published on: November 14, 2010
Effect of random terms on the shape of dendrites analyzed by the phase-field model
Shinya Fujiwara1, Kiyoshiro Okada1, Katsuhiro Endo2
1Department of Science for Open and Environmental Systems, Graduate School of Keio University, Yokohama, Kanagawa, Japan.
Abstract:
In this study, we focus on random terms with a significant effect on the calculation time and the sidebranch structure of dendrites. We quantitatively evaluate the effect of the random terms on dendrites by changing the term introduced into the evaluation equation, the distribution of the random term, and variance. We introduced the terms: [Formula: see text] and [Formula: see text]. In the phase-field equation, we use [Formula: see text] to represent interfacial noise. In the heat conduction equation, we use [Formula: see text] to represent thermal noise. We compare the results of calculation using only [Formula: see text] with those using only [Formula: see text] and analyze the effect of each random term introduced on the shape of dendrites. In terms of the probability distribution for generating random numbers, the uniform and Gaussian distributions are used for comparison. The magnitude of the noise Fu, which controls the variance of noise, is used with 3 or 4 patterns of values to the extent that the calculation results do not diverge. Each value of Fu differs by a factor of 10. Sidebranch length, contour length, and area are used as indices for evaluating dendrites. The succinonitril is used for comparing the simulation and experimental results for dendrites to design the optimal random number model. On the basis of the introduced terms, we clarify that each term requires a different order of the variance. The probability density function of random numbers does not affect the shape of dendrites. On the other hand, the calculation time which is used the random numbers following the uniform distribution is more than twice as fast as when using random numbers that follow a Gaussian distribution. The variance of a random term has the greatest effect on the shape of dendrites.
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