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Prognostic Impact of Estrogen and Progesterone Receptor Expression Across Histological Subtypes and Clinical Factors in Epithelial Ovarian Cancer

Gynecologic and Obstetric Investigation +

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August 4, 2025

|

August 4, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Estrogen receptor (ER) and progesterone receptor (PR) expression in ovarian cancer (OC) varies by subtype. While not impacting overall survival, PR expression showed subtype-specific prognostic value.

Area Of Science

  • Oncology
  • Endocrinology
  • Pathology

Background

  • Hormone receptor (HR) expression is linked to epithelial ovarian cancer (OC) tumorigenesis and survival.
  • Antihormonal therapies demonstrate antitumor activity in OC.

Purpose Of The Study

  • To examine estrogen receptor (ER) and progesterone receptor (PR) expression patterns in OC across histological subtypes.
  • To assess the prognostic value of ER and PR expression in OC disease progression.

Main Methods

  • Retrospective analysis of 164 OC patients treated between 1999 and 2019.
  • Immunostaining and immunoreactive score (IRS) evaluated ER and PR expression.
  • Correlation and survival analyses assessed prognostic and predictive significance.

Main Results

  • ER and PR expression correlated significantly with histological subtypes (p=0.002 and p=0.013).
  • Strong ER/PR expression was common in HGSC, LGSC, and EC; low PR linked to higher tumor grade (p=0.032).
  • CCC patients with weak PR expression had better survival; ER expression showed minimal OS difference. Suboptimal debulking with strong ER expression delayed recurrence (p=0.038).

Conclusions

  • ER and PR expression did not significantly impact overall survival in the entire OC cohort.
  • Prognostic value of ER and PR expression varied significantly by histological subtype and clinical factors.
  • Limitations include single-center design and inability to assess PR isoforms or ER/PR ratios.