Structurally diverse polyketides with herbicidal activity from the fungus Aspergillus aculeatus
Fei Liu1, Shanshan Hong1, Xiaoxia Gu1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
None:
Fifteen undescribed polyketides aculeatides A-O and one known compound xylarinol A were isolated from the endophytic fungus Aspergillus aculeatus. Their structures were identified by spectroscopic data, electronic circular dichroism (ECD) calculations and comparisons, Mo2(OAc)4-induced ECD, Rh2(OCOCF3)4-induced ECD, and the modified Mosher's method. Aculeatides A and B represent the first benzo[c]oxepine derivatives bearing a C6 side chain, while aculeatides C-I possessed a benzofuran ring system featuring a unique C8 side chain. Biologically, aculeatides J and K showed significant herbicidal activities with IC50 values of 3.01 ± 0.40 and 3.33 ± 0.52 μM.
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