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Synthesis of an Intein-mediated Artificial Protein Hydrogel
Published on: January 27, 2014
Therapeutic applications of protein-based hydrogels: Opportunities & challenges
Munishwar Nath Gupta1, Aarti Pawar2, Premlata Ambre3
1Dept of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi 110016, India.
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Protein-based hydrogels offer several advantages over smart hydrogels fabricated with other synthetic or natural polymers when used for therapeutic applications in the areas of drug delivery, tissue engineering and design of dressings for chronic wounds. Their tunable properties, biocompatibility, and biodegradability make them especially suitable for biomedical use. This review points out these advantages, which include the ready availability of chemical and enzymatic crosslinking to tailor their properties. Among proteins, those with repetitive amino acid sequences like elastin-like peptides deserve a special mention.

