Related Experiment Video

Updated: Sep 12, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.4K

Respiratory and Other Infections Following COVID

Andrea J Allen1, Nhat Nguyen1, Vitaly Lorman1

  • 1Applied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Pediatrics
|August 4, 2025
PubMed

Insights

Children who had SARS-CoV-2 infection did not have a higher risk of subsequent respiratory syncytial virus (RSV) or other infections. This study compared infection risks in children with SARS-CoV-2 versus influenza and other respiratory illnesses.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Epidemiology

Background:

  • The 2022 surge in respiratory syncytial virus (RSV) cases prompted investigation into potential contributing factors, including immune suppression following SARS-CoV-2 infection.
  • Understanding the impact of SARS-CoV-2 on subsequent infection risks in children is crucial for public health strategies.

Purpose of the Study:

  • To compare the risk of subsequent respiratory syncytial virus (RSV) and other infections in children with and without prior SARS-CoV-2 infection.
  • To evaluate the association between SARS-CoV-2 infection and the incidence of other respiratory illnesses in pediatric populations.

Main Methods:

  • A retrospective cohort study utilized electronic health records from 27 US health systems.
  • Children under 5 years with SARS-CoV-2 infection were compared to those with influenza or other respiratory tract infections.
  • Inverse probability of treatment weighting and weighted logistic regression were applied to analyze outcomes over 15 to 180 days.

Main Results:

  • Children with SARS-CoV-2 infection showed lower odds of subsequent RSV compared to those with influenza (aOR 0.73) or other respiratory infections (aOR 0.78).
  • The odds of any respiratory tract infection and any infection were also lower in the SARS-CoV-2 group compared to the influenza group.
  • No increased risk of RSV or other infections was observed within 6 months following SARS-CoV-2 infection.

Conclusions:

  • SARS-CoV-2 infection in children was not associated with an increased risk of subsequent RSV, respiratory, or any type of infection within 6 months.
  • Findings suggest that SARS-CoV-2 infection does not heighten susceptibility to other common childhood infections in the short term.
  • The hypothesis of SARS-CoV-2-induced immune suppression leading to increased RSV risk was not supported by this study.
Abstract

More Related Videos

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.2K
Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

5.0K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
330
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
911
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.8K
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
925
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
559
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
208