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Morphine ingestion: genetic control in mice.

G P Horowitz, G Whitney, J C Smith

    Psychopharmacology
    |April 29, 1977
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    Two mouse strains show opposite reactions to morphine sulfate mixed with saccharin. C57BL/6J mice readily consume the solution, while DBA/2J mice avoid it, aiding opiate addiction research.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Genetics

    Background:

    • Opiate addiction is a complex condition with significant public health implications.
    • Understanding the genetic and behavioral factors influencing drug preference is crucial for developing effective treatments.
    • Mouse models are essential for studying the neurobiological underpinnings of drug addiction.

    Purpose of the Study:

    • To investigate strain-specific differences in the acceptance and rejection of morphine sulfate.
    • To establish a model for inducing high levels of morphine ingestion in mice.
    • To identify potential causal factors in opiate addiction through behavioral analysis.

    Main Methods:

    • Utilizing two inbred mouse strains, C57BL/6J and DBA/2J.
    • Administering morphine sulfate dissolved in a sodium saccharin solution.

    Related Experiment Videos

  • Observing and quantifying fluid intake and preference in controlled experimental settings.

    • Main Results:

    • C57BL/6J mice exhibited a strong preference for and high consumption of the morphine-saccharin solution.
    • DBA/2J mice displayed a significant avoidance and low consumption of the same solution.
    • A clear dichotomy in morphine acceptance was observed between the two strains.

    Conclusions:

    • The observed strain-dependent behavioral response to morphine-saccharin provides a valuable model for addiction research.
    • This model can facilitate the identification of genetic and neurobiological factors contributing to opiate preference and addiction.
    • Further research using this model may lead to novel therapeutic strategies for opioid use disorder.