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Updated: Sep 12, 2025

Robot-Assisted Kidney Transplantation
Published on: July 19, 2021
Continuous Kidney Replacement Therapy and Outcomes of Severe Coronavirus Disease 2019 Treated With Extracorporeal
Yoshito Izutani1, Yasumasa Kawano1,2, Akihiro Fujita1
1Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Introduction:
Although continuous kidney replacement therapy (CKRT) for acute kidney injury (AKI) management is common, its effect on the outcomes of patients treated with extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID-19) remains unclear. Therefore, we aimed to investigate the impact of CKRT on the outcomes of these patients.
Methods:
Using a database of patients with severe COVID-19 who required venovenous ECMO across three centers in Japan, we assessed demographics, clinical parameters, and in-hospital mortality rates from January 2020 to December 2021.
Results:
Data of 122 patients treated with ECMO for COVID-19 were analyzed. Forty-five patients required CKRT; the in-hospital mortality rate was 28.7%. Multivariate analysis showed age and CKRT were independent risk factors for in-hospital mortality. The in-hospital mortality rate was significantly higher in the CKRT group.
Conclusion:
CKRT was associated with significantly high in-hospital mortality in patients treated with ECMO for severe COVID-19.
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