Related Experiment Video

Updated: Sep 12, 2025

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

784

Elevated plasma level of PAI-1 is associated with severe COVID-19

Susumu Fukahori1,2, Yurika Kawazoe3, Jung Yeon Han1

  • 1Division of Allergy and Immunology, Department of Internal Medicine, USF Morsani College of Medicine, Tampa, FL, USA.

Scientific Reports
|August 4, 2025
PubMed

Insights

High levels of Plasminogen activator inhibitor-1 (PAI-1) indicate severe coronavirus disease (COVID-19). This endothelial injury marker may predict hospitalization and poor outcomes in COVID-19 patients, suggesting its use in clinical assessment.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Pathophysiology

Background:

  • Endothelial dysfunction is a hallmark of severe coronavirus disease (COVID-19).
  • Plasminogen activator inhibitor-1 (PAI-1) is implicated in endothelial injury and may serve as a prognostic indicator.
  • Understanding PAI-1's role can inform COVID-19 patient management.

Purpose of the Study:

  • To investigate the association between plasma PAI-1 levels and COVID-19 severity.
  • To determine if PAI-1 can serve as a prognostic biomarker for severe COVID-19 outcomes.

Main Methods:

  • Single-center retrospective chart review of 113 hospitalized COVID-19 patients.
  • Plasma PAI-1 levels measured via ELISA.
  • Comparison of PAI-1 levels between severe (ventilator use/death) and non-severe COVID-19 groups.

Main Results:

  • A significant positive correlation was observed between age and PAI-1 levels.
  • Elevated PAI-1 levels were noted in patients with hyperlipidemia.
  • PAI-1 levels were significantly higher in patients requiring mechanical ventilation or who died compared to others.

Conclusions:

  • High plasma PAI-1 levels are significantly associated with severe COVID-19.
  • PAI-1 may function as a valuable biological marker for predicting severe COVID-19 and adverse outcomes.

Keywords:
BiomarkerCOVID-19PAI-1Prognostic factor

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

542
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

Related Concept Videos

Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
492
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
33
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
177
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
24