Related Experiment Video
Updated: Sep 12, 2025

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
Elevated plasma levels of alpha-synuclein are dispensable for Parkinson's disease pathology
Jin-Young Jeong1,2, Namsuk Kim1, Yan Li1
1Neurovascular Biology Laboratory, Neurovascular Unit Research Group, Korea Brain Research Institute, Daegu, Republic of Korea.
Abstract:
Although α-synuclein levels are elevated in the blood plasma of Parkinson's disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD. To investigate this, we developed a novel mouse model in which human α-synuclein levels are increased in the blood. Despite a significant increase in α-synuclein in the blood, no noticeable behavioral abnormalities were observed in aged mice. Additionally, we did not observe plasma α-synuclein aggregation in the blood or entry of human α-synuclein into the brain. These results suggest that elevated blood levels of α-synuclein may not be sufficient to induce PD progression.
More Related Videos
12:01Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
Published on: May 30, 2015
08:33Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
Related Concept Videos
Parkinson's Disease: Overview
Neural Regulation
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Lysosomal Hydrolases