Related Experiment Video
Updated: Sep 12, 2025
Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
Published on: July 23, 2016
Advancements in Liposomal Drug Delivery Systems for Paediatric Neurological Disorders: A Comprehensive Review
Parvathy Hari1, Safa A Vahab1, Vrinda S Kumar2
1Amrita School of Pharmacy, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Kochi, 682041, Kerala, India.
Insights
Liposomes offer a promising way to deliver drugs across the blood-brain barrier for paediatric neurological conditions. This approach enhances drug bioavailability and could improve treatments for disorders like epilepsy and autism.
Area of Science:
- Neuroscience
- Nanotechnology
- Pharmacology
Background:
- Paediatric neurological conditions present unique treatment challenges due to the developing nervous system.
- The blood-brain barrier restricts drug access to the central nervous system, complicating therapeutic interventions.
- Liposomes, as lipid-based drug carriers, show potential for overcoming these delivery obstacles.
Purpose of the Study:
- To review the potential of liposomes in treating paediatric neurological disorders.
- To explore how liposomes can facilitate drug delivery across the blood-brain barrier.
- To highlight the therapeutic advantages of liposomes for various paediatric neurological conditions.
Main Methods:
- Review of existing literature on liposome technology and paediatric neurological disorders.
- Analysis of liposome properties, including surface modification and mechanisms of blood-brain barrier penetration (e.g., endocytosis).
- Discussion of liposome-mediated drug delivery routes (oral, nasal, intravenous) and their impact on bioavailability and toxicity.
Main Results:
- Liposomes can be engineered to cross the blood-brain barrier, enabling targeted drug delivery to the central nervous system.
- Surface modification of liposomes can enhance drug bioavailability through various administration routes.
- Liposomes demonstrate potential for improving therapeutic outcomes in conditions such as epilepsy, migraine, autism, ADHD, and brain tumours.
Conclusions:
- Liposomes represent a significant advancement in drug delivery for paediatric neurological diseases.
- This technology offers a strategy to enhance therapeutic efficacy and reduce toxicity in managing complex paediatric neurological conditions.
- Further research into liposome applications could revolutionize treatment approaches for a range of paediatric neurological disorders.
Abstract:
Paediatric neurological conditions pose many challenges for treatment because of the dynamic properties of the developing nervous system. Special therapeutic interventions are necessary to cope with these alterations because they are frequently impaired by the blood-brain barrier, which denies drugs access to the brain. Liposomes, a lipid carrier, present a promising option, making it possible to deliver a broad variety of drugs to desired locations within the central nervous system. One of the main benefits of liposomes is that they can cross the blood-brain barrier by mechanisms like endocytosis, facilitating controlled drug delivery, minimising toxicity, and enhancing bioavailability. This can be achieved by surface modification of liposomes, enhancing the bioavailability of drugs via oral, nasal, and intravenous routes. In paediatric neurological disorders, liposomes have a great potential in developing treatment approaches, which is discussed in this review. They provide potential therapeutic advantages for ailments like epilepsy, migraine, autism, ADHD, and brain tumours, highlighting their significance in aiding the management of these intricate conditions.
Related Concept Videos
01:29Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
01:21Factors Affecting Drug Response: Overview