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Advancements in Liposomal Drug Delivery Systems for Paediatric Neurological Disorders: A Comprehensive Review
Parvathy Hari1, Safa A Vahab1, Vrinda S Kumar2
1Amrita School of Pharmacy, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Kochi, 682041, Kerala, India.
AAPS Pharmscitech
|August 5, 2025
Summary
Liposomes offer a promising way to deliver drugs across the blood-brain barrier for paediatric neurological conditions. This approach enhances drug bioavailability and could improve treatments for disorders like epilepsy and autism.
Area of Science:
- Neuroscience
- Nanotechnology
- Pharmacology
Background:
- Paediatric neurological conditions present unique treatment challenges due to the developing nervous system.
- The blood-brain barrier restricts drug access to the central nervous system, complicating therapeutic interventions.
- Liposomes, as lipid-based drug carriers, show potential for overcoming these delivery obstacles.
Purpose of the Study:
- To review the potential of liposomes in treating paediatric neurological disorders.
- To explore how liposomes can facilitate drug delivery across the blood-brain barrier.
- To highlight the therapeutic advantages of liposomes for various paediatric neurological conditions.
Main Methods:
- Review of existing literature on liposome technology and paediatric neurological disorders.
- Analysis of liposome properties, including surface modification and mechanisms of blood-brain barrier penetration (e.g., endocytosis).
- Discussion of liposome-mediated drug delivery routes (oral, nasal, intravenous) and their impact on bioavailability and toxicity.
Main Results:
- Liposomes can be engineered to cross the blood-brain barrier, enabling targeted drug delivery to the central nervous system.
- Surface modification of liposomes can enhance drug bioavailability through various administration routes.
- Liposomes demonstrate potential for improving therapeutic outcomes in conditions such as epilepsy, migraine, autism, ADHD, and brain tumours.
Conclusions:
- Liposomes represent a significant advancement in drug delivery for paediatric neurological diseases.
- This technology offers a strategy to enhance therapeutic efficacy and reduce toxicity in managing complex paediatric neurological conditions.
- Further research into liposome applications could revolutionize treatment approaches for a range of paediatric neurological disorders.
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