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Related Experiment Videos

Sensitization to cocaine stimulation in mice.

L Shuster, G Yu, A Bates

    Psychopharmacology
    |April 29, 1977
    PubMed
    Summary

    Repeated cocaine administration in mice leads to long-lasting behavioral sensitization, with effects varying by dose and genetic factors. This cocaine sensitization is specific and not observed with other drugs.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Repeated exposure to psychostimulants like cocaine can induce behavioral sensitization.
    • Understanding the neurobiological and genetic underpinnings of cocaine sensitization is crucial for addiction research.

    Purpose of the Study:

    • To investigate the development, duration, and specificity of behavioral sensitization to cocaine in mice.
    • To explore the influence of genetic factors on cocaine response and sensitization.

    Main Methods:

    • Administration of varying doses of cocaine to B6AF1/J mice over multiple days.
    • Testing cross-sensitization with morphine and d-amphetamine.
    • Assessing the persistence of sensitization and its correlation with catecholamine levels.
    • Comparing cocaine response and sensitization across different mouse strains and recombinant-inbred lines.

    Main Results:

    • Cocaine administration led to a dose-proportional, long-lasting behavioral sensitization (up to 2 months).
    • Sensitization was specific to cocaine; morphine and d-amphetamine showed cross-sensitization effects.
    • No correlation was found between sensitization and whole-brain catecholamine levels.
    • Significant genetic differences in cocaine response and sensitization were observed between parental and recombinant-inbred mouse strains.

    Conclusions:

    • Cocaine induces robust and persistent behavioral sensitization in mice.
    • The development of cocaine sensitization is influenced by genetic factors, suggesting distinct genetic determinants for initial response and sensitization.
    • These findings contribute to understanding the neurogenetic basis of stimulant addiction.

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