Related Experiment Video
Updated: Sep 12, 2025
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
RANK-ligand inhibition to combat sarcopenia with underlying osteoporosis: a study protocol for a randomized,
Ronald Man Yeung Wong1, Pui Yan Wong2, Chaoran Liu2
1Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China. ronald.wong@cuhk.edu.hk.
Background:
Sarcopenia is an age-related disease characterized by gradual loss of muscle strength and muscle mass. Osteosarcopenia is the presence of osteopenia/osteoporosis and sarcopenia, which poses an increased risk of falls and fractures. Currently, there is no Food and Drug Administration (FDA) approved drug for treating sarcopenia. Previous studies showed that nuclear factor-κB ligand (RANKL) inhibition could reduce muscle atrophy and could be a therapeutic target for treating sarcopenia. Denosumab is an anti-osteoporotic drug with RANKL inhibition. This study aims to investigate the effects of denosumab to treat sarcopenia in patients with underlying osteoporosis.
Methods:
This study is a randomized, double-blind, double-dummy, active-controlled trial for investigating the efficacy of denosumab in treating sarcopenia in patients with osteosarcopenia. Participants aged 65 years or above with osteosarcopenia will be recruited. Participants will be randomized into the denosumab group or the zoledronic acid group and will be followed up for 1 year. The primary outcomes are muscle strength, muscle mass measured by dual-energy x-ray absorptiometry (DXA) scan, and physical performance. The secondary outcomes are the clinical outcomes, including fall rate, fracture rate and mortality.
Discussion:
This study will study the potential therapeutical effects of denosumab (RANKL inhibitor) on osteosarcopenia, which will be crucial given the aging population and expected increase in disease numbers.
Trial Registration:
ClinicalTrials.gov, NCT06643780. Registered on 16 October 2024. (Retrospectively registered and no protocol changes were made since the recruitment was started for this study).
