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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

44
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
44
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

20
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
20
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

30
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
30
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

18
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
18

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Related Experiment Video

Updated: May 3, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

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Published on: November 19, 2008

35.9K

Neonatal cerebral infarction: A case report.

Zhonghua Hu1, Chengchao Fang, Yueyan Mao

  • 1Department of Pediatrics, The First Affiliated Hospital of Linping District , Hangzhou, China.

Medicine
|August 5, 2025
PubMed
Summary

Neonatal cerebral infarction presents diverse forms and outcomes. Early diagnosis via imaging and consistent follow-up are crucial for managing potential long-term neurological effects in infants.

Keywords:
caseinfantneonatalneonatal cerebral infarction

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Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
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Last Updated: May 3, 2026

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35.9K
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
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Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
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Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

838

Area of Science:

  • Neurology
  • Pediatrics
  • Medical Imaging

Background:

  • Neonatal cerebral infarction (NCI) is a significant cause of neurological disability in newborns.
  • NCI can manifest in various forms, including focal or widespread, clinically silent or severe, and related to embolism, thrombosis, prenatal, or postnatal events.
  • Hemorrhagic or occlusive types of NCI present distinct clinical challenges.

Purpose of the Study:

  • To describe the diagnosis and initial management of a case of neonatal cerebral infarction.
  • To highlight the potential for delayed neurological deficits following NCI.
  • To emphasize the importance of ongoing monitoring and rehabilitation for affected infants.

Main Methods:

  • Diagnosis of neonatal cerebral infarction was confirmed postnatally.
  • Advanced neuroimaging techniques, including computed tomography (CT) and magnetic resonance imaging (MRI), were employed to assess the extent of cerebral infarction.
  • Fluid restriction and dehydration were utilized as interventions to manage intracranial pressure.

Main Results:

  • Infants diagnosed with neonatal cerebral infarction may not exhibit immediate hemiparesis.
  • Progressive development of left hemiplegia asymmetry can become apparent over several months post-birth.
  • The long-term neurological sequelae of NCI require careful observation.

Conclusions:

  • Predicting language development outcomes in infants with neonatal stroke remains challenging.
  • Regular outpatient clinic follow-up is essential for monitoring infant development.
  • Timely initiation of rehabilitation exercise training is recommended when necessary to optimize functional recovery.