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PAK1 Signaling in Cancer: Multifaceted Roles and Therapeutic Implications

Faiz Meman1, Divya Tandel1, Archana Navale1

  • 1Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Limda, Waghodia, Vadodara, Gujarat, India.

Current Gene Therapy
|August 5, 2025
PubMed

Insights

p21-activated kinase 1 (PAK1) is crucial in cancer progression, affecting cell growth, blood vessel formation, and metastasis. Understanding PAK1

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • p21-activated kinase 1 (PAK1) is a serine-threonine kinase.
  • PAK1 functions as a downstream effector for Rho GTPases like Rac, Ras, and CDC42.
  • These GTPases are critical regulators in numerous oncogenic signaling pathways.

Purpose of the Study:

  • To elucidate the multifaceted roles of PAK1 in cancer biology.
  • To highlight PAK1's significance in key oncogenic signaling pathways.
  • To underscore PAK1 as a potential therapeutic target for cancer intervention.

Main Methods:

  • Review and synthesis of existing literature on PAK1.
  • Analysis of PAK1's involvement in cellular processes.
  • Examination of PAK1's influence on therapeutic resistance.

Main Results:

  • PAK1 is implicated in cell cycle regulation, angiogenesis, and metastasis.
  • PAK1 plays a role in the development of therapeutic resistance in various cancers.
  • PAK1 acts as a central node in diverse signaling pathways driving cancer progression.

Conclusions:

  • Comprehensive understanding of PAK1's functions is vital for cancer research.
  • PAK1 represents a promising target for developing novel cancer therapies.
  • Targeted interventions focusing on PAK1 may improve cancer diagnostics and treatment outcomes.
Keywords:
Cancer biologyMAPK cascadeanti-cancer agentsautophagy in cancer.cellular signalingkinase inhibitorssmall GTPasestumor microenvironment

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