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Updated: Sep 12, 2025

Preparation of Biopolymer Aerogels Using Green Solvents
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Nanofiber Aerogels: Recent Progress and Biomedical Applications.

Syed Muntazir Andrabi1, Navatha Shree Sharma1, S M Shatil Shahriar1

  • 1Department of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

ACS Applied Materials & Interfaces
|August 5, 2025
PubMed
Summary

Nanofiber aerogels blend aerogel properties with nanofibers for advanced biomaterials. Fabrication methods are reviewed for tunable structures and diverse biomedical applications, from tissue engineering to biosensing.

Keywords:
aerogel microspheresbiomedical applicationsexpanded scaffoldsfabricationnanofiber aerogels

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Last Updated: Sep 12, 2025

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Materials Engineering

Background:

  • Nanofiber aerogels combine high surface area, porosity, and lightweight properties of aerogels with tunable nanofiber architectures.
  • These materials offer unique structural, mechanical, and biofunctional characteristics for advanced applications.

Purpose of the Study:

  • To provide an in-depth analysis of fabrication strategies for nanofiber aerogels.
  • To focus on methods enabling precise control over structural, mechanical, and functional characteristics.
  • To explore the biomedical potential and challenges of nanofiber aerogels.

Main Methods:

  • Systematic review of key fabrication techniques: sol-gel processing, gas foaming, freeze-casting, electrospinning-assisted assembly, 3D printing, and template-guided synthesis.
  • Discussion on how each method influences aerogel architecture, performance, and application potential.
  • Emphasis on additive manufacturing for customized geometries and improved reproducibility.

Main Results:

  • Fabrication methods significantly influence nanofiber aerogel architecture, mechanical properties, and performance.
  • Additive manufacturing enables tailored external geometries for personalized biomedical devices.
  • Exploration of diverse biomedical applications including tissue engineering, drug delivery, hemostasis, wound healing, and biosensing.

Conclusions:

  • Nanofiber aerogels show significant promise across various biomedical fields.
  • Key challenges include scalability, biocompatibility, biostability, and regulatory hurdles.
  • Emerging technologies and multidisciplinary approaches are crucial for clinical translation.