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Proton minibeam radiotherapy: a review
Feng Yang1,2, Junxiang Wu1, Lucia Clara Orlandini1
1Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Radiation Oncology Key Laboratory of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Proton minibeam radiotherapy (pMBRT) offers improved cancer treatment by delivering targeted radiation doses, minimizing normal tissue damage. This review explores preclinical pMBRT applications, challenges, and its promising future in oncology.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Radiotherapy is a cornerstone of cancer treatment.
- Spatially fractionated radiotherapy (SFRT) optimizes therapeutic ratio by creating high and low dose regions.
- Proton minibeam radiotherapy (pMBRT) is an advanced SFRT technique with potential benefits.
Purpose of the Study:
- To evaluate preclinical applications of proton minibeam radiotherapy (pMBRT).
- To explore the challenges in translating pMBRT to clinical practice.
- To highlight the future potential of pMBRT in cancer therapy.
Main Methods:
- Review of preclinical research studies on pMBRT.
- Analysis of outcomes related to dose distribution, tumor control, and normal tissue sparing.
- Exploration of translational challenges and future prospects.
Main Results:
- pMBRT demonstrates potential for optimized dose distribution.
- Preclinical studies suggest enhanced tumor control and normal tissue preservation with pMBRT.
- Significant challenges exist in the clinical translation of pMBRT.
Conclusions:
- pMBRT shows promise as an advanced radiotherapy technique.
- Further research and development are needed to overcome clinical translation barriers.
- pMBRT holds significant potential for future cancer treatment strategies.
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