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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

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Published on: October 7, 2016

Hydrogels and nanogels: effectiveness in dermal applications.

Jéssica da Cruz Ludwig¹, Diana Fortkamp Grigoletto¹, Daniele Fernanda Renzi¹

¹Pharmacy Department, Applied Nanoestructured Systems Laboratory, Universidade Estadual do Centro-Oeste, Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167 - Bairro - Vila Carli, Guarapuava - PR, Brazil.

Beilstein Journal of Nanotechnology

|August 5, 2025

Summary

Drug delivery systems (DDSs), including hydrogels and nanogels, offer improved drug properties for dermal applications. These biocompatible systems enhance drug stability, absorption, and skin permeation, showing promise for innovative treatments.

Keywords:

cross-linking drug delivery formulation nanogel polymer

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Materials Science
Pharmaceutical Sciences
Biotechnology

Background:

Drug delivery systems (DDSs) are crucial for overcoming drug limitations like poor stability, absorption, and biodistribution.
Hydrogels and nanogels are prominent DDSs due to their ease of preparation, biocompatibility, and versatility.
Chitosan and alginate are key natural polymers utilized in hydrogel formulation.

Purpose of the Study:

To review hydrogels and nanogels as advanced drug delivery systems.
To explore their preparation methods and applications in dermal and ocular administration.
To highlight their potential in enhancing drug permeation for treating skin conditions.

Main Methods:

Review of existing literature on hydrogels and nanogels for drug delivery.
Discussion of polymer-based hydrogel preparation techniques (e.g., using chitosan and alginate).
Analysis of nanogel properties, including drug encapsulation and penetration enhancement.

Main Results:

Hydrogels and nanogels demonstrate significant potential as drug carriers.
These systems can be tailored for improved drug physicochemical properties and targeted delivery.
Incorporation of drugs into these nanocarriers enhances skin permeation for dermal applications.

Conclusions:

Hydrogels and nanogels represent promising innovations in drug delivery, particularly for dermal administration.
Their biocompatibility and tunable properties facilitate enhanced drug efficacy and patient compliance.
Further research into these DDSs could lead to novel therapeutic strategies for various skin diseases.