Related Experiment Video
Updated: Sep 12, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Dapagliflozin-Associated Hepatotoxicity With a Positive Rechallenge
Yusuf Alawadhi1, Ali Abdolall2, Christopher Cunningham3
1Department of Medicine Michigan Medicine, Ann Arbor, MI.
None:
Sodium glucose cotransporter 2 inhibitors are generally safe medications, with labelled indications for diabetes mellites, heart failure, and chronic kidney disease. We present a case of suspected dapagliflozin-induced liver injury in a 68-year-old man who presented with 2 weeks of upper abdominal pain, myalgias, and transaminitis following a prior episode of unexplained hepatitis. It was determined that the patient's liver injury with jaundice was likely due to dapagliflozin with a Revised Electronic Causality Assessment Method (RECAM) score of 9 (Highly likely). Laboratory findings and clinical symptoms resolved after discontinuing dapagliflozin during follow up.
More Related Videos
Related Concept Videos
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: Biguanides and Glitazones
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: Sulfonylureas

