Bioactive LDH nanoplatforms for cancer therapy: Advances in modulating programmed cell death

Area of Science:

• Nanotechnology
• Tumor Biology
• Materials Science

Background:

• Nanotechnology and tumor biology advancements enable new cancer therapies.
• Layered double hydroxides (LDH) are 2D nanomaterials with tunable structures, biocompatibility, and drug delivery potential.
• LDH show promise in modulating programmed cell death (PCD) pathways in cancer cells.

Purpose of the Study:

• To provide a comprehensive overview of using LDH in cancer therapy.
• To highlight LDH's role in regulating diverse PCD pathways (apoptosis, autophagy, ferroptosis, cuproptosis, pyroptosis).
• To discuss mechanisms, material design, and precise cancer therapy applications of LDH.

Main Methods:

• Literature review of recent research on LDH in cancer therapy.
• Analysis of underlying mechanisms of LDH-induced PCD.
• Examination of material design strategies for bioactive LDH.

Main Results:

• LDH can effectively modulate multiple PCD pathways in cancer cells.
• Specific material design strategies enhance LDH efficacy in cancer treatment.
• LDH applications in precise cancer therapy are expanding.

Conclusions:

• LDH represent a promising class of nanomaterials for cancer therapy.
• Further research is needed to address challenges and optimize bioactive LDH for clinical application.
• Future perspectives focus on overcoming bottlenecks for effective cancer treatment.