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Related Experiment Video

Updated: Sep 12, 2025

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
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Lower Extremity Targeted Muscle Reinnervation for Mononeuropathy in Nonamputation Patients: Techniques and Tips.

Kelly A Kugach1,2, Camden Novikova2, Rachel Schwartz3

  • 1From the Department of Orthopaedic Surgery, Foot and Ankle, Carilion Clinic, Roanoke, VA.

Plastic and Reconstructive Surgery. Global Open
|August 5, 2025
PubMed
Summary

Targeted muscle reinnervation (TMR) offers a new treatment for painful neuropathies. This study details TMR techniques for the lower extremities in nonamputation patients, addressing a previously unmet clinical need.

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Area of Science:

  • Neurosurgery
  • Orthopedics
  • Pain Management

Background:

  • Painful mononeuropathies are common and challenging to treat in nonamputation patients.
  • Targeted muscle reinnervation (TMR) effectively reduces pain in amputation patients and those with neuromas.
  • Limited information exists regarding TMR application and techniques in nonamputation patient populations.

Purpose of the Study:

  • To present surgical techniques for performing TMR in the lower extremities of nonamputation patients.
  • To provide practical tips and tricks for executing these novel TMR procedures.
  • To review the rationale behind recipient muscle selection for lower extremity TMR in this patient group.

Main Methods:

  • Cadaveric dissection was utilized to develop and illustrate TMR techniques.
  • Surgical videos were employed to demonstrate the practical application of these methods.
  • A review of recipient muscle selection criteria for lower extremity TMR was conducted.

Main Results:

  • Detailed techniques for lower extremity TMR in nonamputation patients were established.
  • Practical guidance, including tips and tricks, for performing the procedures was provided.
  • The rationale for selecting specific recipient muscles was elucidated.

Conclusions:

  • This work establishes foundational techniques for lower extremity TMR in nonamputation patients.
  • The described methods offer a potential new treatment avenue for painful mononeuropathies in this population.
  • Further research and clinical application are warranted to validate TMR's efficacy for neuropathic pain.