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Updated: Sep 12, 2025

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Published on: November 14, 2016

Neurologists' Openness to Evidence-Based Innovation in Multiple Sclerosis Care: Individual and Structural

Enric Monreal¹, Rocío Gómez-Ballesteros², Virginia Meca-Lallana³

¹Department of Neurology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Neuropsychiatric Disease and Treatment

|August 5, 2025

Summary

Neurologists show varied openness to adopting new multiple sclerosis (MS) innovations like serum neurofilament light chain (sNfL) testing. Prioritizing neurologists with higher empathy and access to sNfL testing can facilitate the integration of personalized MS care strategies.

Keywords:

decision-making innovation multiple sclerosis neurofilament light chain personalized medicine

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Area of Science:

Neurology
Healthcare Innovation Adoption
Personalized Medicine

Background:

Integrating evidence-based innovations, such as serum neurofilament light chain (sNfL) testing, is crucial for advancing personalized care in multiple sclerosis (MS) management.
Understanding neurologists' attitudes towards adopting new healthcare technologies is essential for successful implementation.

Purpose of the Study:

To assess neurologists' openness to adopting healthcare innovations, specifically sNfL testing.
To identify individual characteristics and workplace factors influencing neurologists' adoption of innovations in MS care.

Main Methods:

An observational, cross-sectional study involving 116 neurologists in Spain.
Utilized an e-survey to measure openness to innovation (using EBPAS-Openness scale), empathy, risk preferences, burnout, and workplace communication.
Employed logistic and linear regression to determine predictors of innovation adoption.

Main Results:

54.3% of neurologists demonstrated openness to innovation.
Access to sNfL testing (OR=3.52) and higher empathy levels (OR=1.09) were significant predictors of openness.
A positive association was found between higher EBPAS-Openness scores and empathy (estimate=0.024).

Conclusions:

Neurologists' openness to innovation in MS care is varied.
Prioritizing neurologists with specific profiles, such as those with higher empathy and access to sNfL testing, can enhance the integration of new tools and personalized approaches in MS management.